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Recently, GLP-1/GIP/Glucagon receptor triagonists have been in development and clinical trials

(2009) 297:C112432

Instead they rose out of the quest to unravel the complex physiology of the gut and its diseases, particularly diabetes

Obesity is associated with reduced testosterone levels in men, while in women, obesity often increases free androgens and decreases sex hormone binding globulin (SHBG), particularly in conditions like polycystic ovary syndrome (PCOS)

These drugs, once used mainly for diabetes, slow how quickly the stomach empties, leaving people feeling full for longer than they would without the medication